_341_ _Objectives: _In patients with multivessel disease both the detection of the culprit lesion and the exact allocation are important preconditions for sufficient treatment and improved outcome. In a vessel based approach the combination of quantitative coronary angiography and fractional flow reserve measured by a pressure wire should be advantageous compared to myocardial SPECT, as morphological and functional information is delivered simultaneously. Therefore our aim was to evaluate MS in the detection and allocation of hemodynamically significant stenoses obtained by the (...) combined gold standard QCA plus FFR in patients with multivessel disease. _Methods: _FFR and QCA of 95 vessels in 80 patients have been evaluated. Hemodynamically significant target lesions were defined as intermediate stenoses between 50 and 75% with an FFR. (shrink)

Over 40 years of research have shown that traumatic brain injury affects brain volume. However, technical and practical limitations made it difficult to detect brain volume abnormalities in patients suffering from chronic effects of mild or moderate traumatic brain injury. This situation improved in 2006 with the FDA clearance of NeuroQuant®, a commercially available, computer-automated software program for measuring MRI brain volume in human subjects. More recent strides were made with the introduction of NeuroGage®, commercially available software that is based (...) on NeuroQuant® and extends its utility in several ways. Studies using these and similar methods have found that most patients with chronic mild or moderate traumatic brain injury have brain volume abnormalities, and several of these studies found—surprisingly—more abnormal enlargement than atrophy. More generally, 102 peer-reviewed studies have supported the reliability and validity of NeuroQuant® and NeuroGage®. Furthermore, this updated version of a previous review addresses whether NeuroQuant® and NeuroGage® meet the Daubert standard for admissibility in court. It concludes that NeuroQuant® and NeuroGage® meet the Daubert standard based on their reliability, validity, and objectivity. Due to the improvements in technology over the years, these brain volumetric techniques are practical and readily available for clinical or forensic use, and thus they are important tools for detecting signs of brain injury. (shrink)

This first volume in a series entitled Founders of Modern Political and Social Thought, by John Finnis, Professor of Law and Legal Philosophy at Oxford, is the most comprehensive and detailed treatment in print of Aquinas’s political and ethical thought. Finnis is already well known for his 1980 book, Natural Law and Natural Rights, his Thomistic-inspired theory of “basic human goods” in Fundamentals of Ethics, and his attack on the morality of nuclear deterrence, written with Joseph Boyle and Germain (...) Grisez. The present work is an effort to understand and critique Aquinas’s political and ethical thought as philosophy rather than theology, to correct what Finnis considers “one-sided or wrong” beliefs about his thinking, and to see how well it stands up as “a critical theory” today. Thanks to modern technology, Finnis is able to draw upon the full sixty volumes of Aquinas’s works, over 8.5 million words, rather than restricting the discussion as earlier works have done, to the early Commentary on the Sentences, the two Summas, and his advice to the King of Cyprus. (shrink)

The main idea in this series of essays is that subjective awareness depends upon the intralaminar nuclei of each thalmus. This implies that the internal structure and external relations of ILN make subjective awareness possible. An array of material relevant to this proposal was briefly reviewed in Part I. This Part II considers in more detail some semantic aspects and a bit of philosophic background as these pertain to propositions 0, 1, and 2 of Part I. Part II should be (...) read in conjunction with Part I. (shrink)

ABSTRACT The main cause of the crisis was the behavior of the banks—largely a result of misguided incentives unrestrained by good regulation. Conservative ideology, along with unrealistic economic models of perfect information, perfect competition, and perfect markets, fostered lax regulation, and campaign contributions helped the political process along. The banks misjudged risk, wildly overleveraged, and paid their executives handsomely for being short‐sighted; lax regulation let them get away with it—putting at risk the entire economy. The mortgage brokers neglected due diligence, (...) since they would not bear the risk of default once their mortgages had been securitized and sold to others. Others can be blamed: the ratings agencies that judged subprime securities as investment grade; the Fed, which contributed low interest rates; the Bush administration, whose Iraq war and tax cuts for the rich made low interest rates necessary. But low interest rates can be a boon; it was the financial institutions that turned them into a bust. (shrink)

What, precisely, is `salt'? It is a certainwhite, solid, crystalline, material, alsocalled sodium chloride. Does any of that solidwhite stuff exist in the sea? – Clearly not.One can make salt from sea water easily enough,but that fact does not establish thatsalt, as such, is present in brine. (Paper andink can be made into a novel – but no novelactually exists in a stack of blank paper witha vial of ink close by.) When salt dissolves inwater, what is present is no (...) longer `salt' butrather a collection of hydrated sodium cationsand chloride anions, neither of which isprecisely salt, nor is the collection. Theaqueous material in brine is also significantlydifferent from pure water. Salt may beconsidered to be present in seawater, but onlyin a more or less vague `potential' way.Actually, there is no salt in the sea. In bothancient and modern treatments of otherimportant chemical concepts, including thenotions of `element', related complication,especially polysemy (terms with multiplemeanings), also occurs.In a recent paper, Paul Needham discussed the(predicable) properties of chemical substances,phases, and solutions. He provided a valuablecharacterization of cases in which severalquantities occupy the same space. He alsoconcluded that solution properties are not`intensive', because solvent and solute do nothave parts in common. He tacitly assumed thatingredients are not altered by their inclusionin a solution. This may be the case in somespecial cases (deutero-benzene dissolved inbenzene, say) but is not true in general – andcertainly does not apply to the case of brine,which Needham used as an example – since theions that exist in the solution, and also theaqueous material there, are quite differentfrom the pure ingredients used in making thesolution. An adequate theory of wholes andparts (mereology) must take into account thatwhen individuals enter combinations ofinteresting sorts they no longer are the verysame individuals that existed prior to thecomposition. It appears that no such formaltheory now actually exists. (shrink)

One of the main functions that introductory chemistry courses have fulfilled during the past century has been to provide evidence for the general validity of 'the atomic hypothesis.' A second function has been to demonstrate that an analytical approach has wide applicability in rationalizing many kinds of phenomena. Following R.G. Collingwood, these two functions can be recognized as related to a philosophical 'cosmology' (worldview, weltanshauung) that became dominant in the later Renaissance. Recent developments in many areas of science, and in (...) chemistry, have emphasized the central importance of understanding synthetic, developmental, and evolutionary aspects of nature. This paper argues that these scientific developments, and changes in other aspects of culture, amount to a widespread shift to an alternative cosmology, a quite different general worldview. To the extent that this is the case, introductory chemistry courses ought to be changed in fundamental ways. Rather that having a main focus on analysis to microscopic components, introductory chemistry instruction should emphasize current scientific understanding of the (synthetic) evolutionary origins of the present world. This altered approach would provide good preparation for future professional work, while also making better contact with the perceived concerns of students. (shrink)

How certain neural mechanisms momentarily endow with the subjective awareness percepts and affects represented elsewhere is more likely to be clarified when structures essential to Mc are identified. The loss of C with bilateral thalmic lesions involving the intralaminar nuclei contrasts with retention of C after large cortical ablations depriving C of specific contents. A role of ILN in the perception of primitive sensations is suggested by their afference of directly ascending pathways. A role for ILN in awareness of cortical (...) activity is suggested by their widespread afference from cortex, a property shared with striatum. A role for ILN in volition is suggested by their heavy projection to striatum. Unlike striatum, ILN also project widely to almost all neocortex, enabling an effect on ideation; this last property is in common with other structures but none of them has the same direct cortical afference. And passage through the reticular nucleus of ILN efferents to cortex could impact the attention-selective action of nRt. It is suggested that the quickest route to a better understanding of C involves more intensive study of ILN. No other structure seems, in the light of our current knowledge, a more likely site for Mc. (shrink)

The work is the presentation of a logical theory - Logic in Reality (LIR) - and of applications of that theory in natural science and philosophy, including ...

This article grapples with the causes of India’s microfinance crisis. By contrasting Bangladesh’s highly successful Grameen model with the allegedly “universalizable” version of India’s SKS Microfinance, trust or social capital is isolated—not just narrowly interpreted within standard economic theory, but more broadly construed—as the essential element accounting for the early success of microfinance. It is argued that the microfinance experience has been widely misinterpreted, in both analytical and policy terms. This article suggests inherent limits in extending the model to for-profit (...) institutions and, in particular, to the pace of scaling up. (shrink)

'Fear' is used scientifically in two ways, which causes confusion: it refers to conscious feelings and to behavioral and physiological responses. Restricting the use of 'fear' to denote feelings and using 'threat-induced defensive reactions' for the responses would help avoid misunderstandings about the brain mechanisms involved.

The Ashgate Research Companion to Islamic Law. Edited by Rudolph Peters and Peri Bearman. Farnham, Surrey, UK: Ashgate, 2014. Pp. x + 345. $149.95, £95.

While it is common to think that neuroscientists are proponents of basic emotions theory, this is not necessarily the case. My ideas, for example are more aligned with cognitive than basic emotions theories.

In the characterization of the ArCl2 'van der Waals complex', a recognizable pattern of well-defined peaks is observed in the microwave absorption spectrum. In the control of chaos in a chemical oscillatory reaction the power spectrum progressively becomes simpler, at length yielding a single peak. Since both of these cases generate coherences that are centers of agency, they should be considered to produce new chemical entities. Applicability of this ontological approach to coherences of wider societal interest is suggested.

The term intersectionality, which is generally attributed to Kimberlé Crenshaw, began as a metaphorical and conceptual tool used to highlight the inability of a single-axis framework to capture the lived experiences of black women. Whilst many disciplines have used the ‘tools’ of intersectionality before 1989, modern day usage of the term is usually associated with Crenshaw’s specific approach. The development of Crenshaw’s intersectionality, originated from the failure of both feminist and anti-racist discourse; to represent and capture the specificity of the (...) discrimination faced by black women. This failure resulted from an inability to identify the multiple grounds which constitute an... (shrink)

Are the conclusions reached by mature sciences merely “likely stories” or are they “really true”? Questions of this sort have been live issues from Étienne Tempier’s March 1277 condemnation of theses of the Radical Aristotelians of Paris to the May 2005 Kansas State Board of Education deliberations on Darwinism. One major difficulty with the view that scientific findings are “really true” is that, from the historical record, all such statements are recognized as being revisable, even replaceable. Several attempts to formalize (...) a notion of “approximate truth” have addressed this difficulty—without notable success. This book proposes a new solution to the problem—a resolution that stands in the tradition of the American Pragmatists: Peirce, James, and Dewey. (shrink)

ABSTRACTMichelle Amazeen's rebuttal of Uscinski and Butler 2013 is unsuccessful. Amazeen's attempt to infer the accuracy of fact checks from their agreement with each other fails on its own terms and, in any event, could as easily be explained by fact checkers’ political biases as their common access to the objective truth. She also ignores the distinction between verifiable facts and unverifiable claims about the future, as well as contestable claims about the causes of political, social, and economic phenomena. The (...) social benefits that she claims for the fact-checking enterprise must, at the very least, be weighed against the strong possibility that what passes for fact checking is actually just a veiled continuation of politics by means of journalism rather than being an independent, objective counterweight to political untruths. (shrink)

Bertrand Russell was perhaps the last great philosopher to take an active interest in economics. After a brief, youthful engagement with the economics of socialism in 1889, Russell wrote on economic questions in three separate periods up to 1918, and in each case there was a clear political motivation. The first, in 1895–96, arose from his investigation of Marxism as a creed and of German social democracy as its principal contemporary political expression. The second, in 1903–04, was provoked by his (...) intervention on the free trade side of the tariff controversy. Finally, in 1915–18, Russell's commitment to Guild Socialism and to war resistance led him to some profound, if rather speculative, reflections on the economics of libertarian socialism. In this paper I discuss each of these three phases in Russell's economic thought and conclude that he never went far enough in his opposition to neo-classical theory in general, or to its utilitarian foundations in particular. (shrink)

Each of these books presents a new paradigm of nature and couples it with a convincing explanation of how our right brain hemispheres have a unique ability to ...

Aware of the decline and imminent demise of many integrated steel mills in the United States and fascinated by their monumental architecture, machinery, and the culture of work and community that was inextricably connected to them, Joseph Elliott photographed the mills in Bethlehem, Pennsylvania from 1989 until final shutdown in 1997. This book appeals to the growing fascination with industrial archaeology and will be an inspiration for the preservation and re-use of these relic structures.

While engaging in rich discussion, Conspiracy Theories analyzes current arguments and evidence while providing real-world examples so students can contextualize and visualize the debates. Each chapter addresses important current questions, provides conceptual tools, defines important terms, and introduces the appropriate methods of analysis.